{"id":277,"date":"2019-01-22T07:22:55","date_gmt":"2019-01-22T07:22:55","guid":{"rendered":"https:\/\/cifra2-cm.com\/?page_id=277"},"modified":"2023-11-17T07:19:11","modified_gmt":"2023-11-17T07:19:11","slug":"grupo-cifra2-uah","status":"publish","type":"page","link":"https:\/\/cifra2-cm.com\/index.php\/grupo-cifra2-uah\/","title":{"rendered":"Grupo CIFRA2-UAH"},"content":{"rendered":"

Grupo Cifra 2 – UAH<\/h1>\n

\"\"<\/p>\n

Ricardo Jos\u00e9 Bosch Mart\u00ednez<\/h1>\n

Francisco J. de Lucio Caza\u00f1a<\/h1>\n
\n

\"\"Ricardo J Bosch.<\/strong> Catedr\u00e1tico em\u00e9rito del Dpto Biol Sistemas, UAH . Investiga en el \u00e1rea de la nefropat\u00eda inducida por el factor ambiental bisfenol A (BFA) y la nefropat\u00eda diab\u00e9tica (ND). Actualmente se est\u00e1n realizando estudios traslacionales en poblaciones de alto y bajo nivel de exposici\u00f3n al BFA. Estudios preliminares muestran niveles de exposici\u00f3n al BFA m\u00e1s altos de lo esperado, as\u00ed como una correlaci\u00f3n significativa entre excreci\u00f3n urinaria de BFA y la podocituria; hallazgo que requiere del an\u00e1lisis de un n\u00famero significativo de muestras humanas de diferentes grupos poblacionales en aras de identificar el papel real de esta nueva nefropat\u00eda en la poblaci\u00f3n espa\u00f1ola.<\/p>\n<\/div>\n

\n

\"\"Francisco Javier de Lucio<\/strong> es actualmente Catedr\u00e1tico de Fisiolog\u00eda en la Universidad de Alcal\u00e1. Su investigaci\u00f3n se ha dirigido al campo de la inflamaci\u00f3n en aspectos como sus relaciones con el envejecimiento, los efectos de los radicales libres de ox\u00edgeno, la producci\u00f3n de matriz extracelular y la fibrosis, el dolor y las enfermedades renales. En los \u00faltimos a\u00f1os se ha centrado en el fracaso renal agudo y el papel que juegan en el mismo mecanismos dependientes de prostaglandina E2 intracelular. Se trata de un novedoso concepto que explora el papel patol\u00f3gico de PGE2 en el c\u00e1ncer del pr\u00f3stata y el fracaso renal agudo actuando sobre receptores intracelulares (frente al concepto cl\u00e1sico de los mecanismos mediados por receptores de membrana).<\/p>\n<\/div>\n

Rafael Ramirez-Chamond<\/h1>\n

Matilde Alique<\/h1>\n
\n

\"\"Catedr\u00e1tico Fisiolog\u00eda<\/strong>, Dpto Biolog\u00eda de Sistemas- Estudia el papel de ves\u00edculas extracelulares procedentes de c\u00e9lulas endoteliales en la fisiopatolog\u00eda del da\u00f1o cardiovascular en enfermos con insuficiencia renal. Este grupo est\u00e1 integrado en el Instituto de Investigaci\u00f3n Sanitaria Ramon y Cajal, as\u00ed como en la Universidad de Alcal\u00e1. Adem\u00e1s, sus \u00faltimos proyectos est\u00e1n basados en la hip\u00f3tesis de que la enfermedad cardiovascular (ECV) aparece como un resultado del proceso fisiol\u00f3gico de un envejecimiento prematuro endotelial, desarroll\u00e1ndose senescencia celular que puede desencadenar la calcificaci\u00f3n vascular.<\/p>\n<\/div>\n

\n

\"\"Profesora Titular del Dpto Biolog\u00eda de Sistemas.<\/strong> La Dra. Alique realiz\u00f3 varias estancias postdoctorales tanto a nivel nacional como internacional, destacando su estancia en el laboratorio del Dr. Badimon en el Hospital Mount Sinai (NYC) para ampliar su experiencia en enfermedades cardiovasculares. En 2011 consigui\u00f3 un contrato postdoctoral Sara Borrell (ISCIII) para trabajar en la Unidad de Nefrolog\u00eda e Hipertensi\u00f3n (IIS-FJD) bajo a la supervisi\u00f3n de la Dra. Ruiz-Ortega. En 2015 se incorpor\u00f3 al grupo del Dr. Ram\u00edrez y su trabajo se bas\u00f3 en el papel de las microves\u00edculas en el da\u00f1o endotelial asociada con la enfermedad renal cr\u00f3nica. Desde el 2018 compagina su labor docente primero como Prof. Ayudante Doctor y recientemente como Profesora Titular, con su l\u00ednea de investigaci\u00f3n centrada en el estudio de las microves\u00edculas como mediador de calcificaci\u00f3n vascular. Su contribuci\u00f3n cient\u00edfica hasta la fecha se refleja en 57 publicaciones indexadas en Pubmed, que se han citado 1842 veces y un \u00edndice h de 27. Ha participado en m\u00e1s de 60 comunicaciones internacionales y nacionales, siendo orador invitado en 17 ocasiones.<\/p>\n<\/div>\n

Lineas de investigaci\u00f3n<\/h1>\n
\n

Nefropat\u00eda diab\u00e9tica experimental, PTHrP, FRA y nefropat\u00eda cardiopat\u00eda por BFA.<\/p>\n<\/div>\n

Lineas de investigaci\u00f3n<\/h1>\n
\n

Prostaglandina E2 intracelular en la fisiolog\u00eda y patolog\u00eda del t\u00fabulo proximal y como factor protumoral en neoplasias benignas y malignas de pr\u00f3stata.<\/p>\n<\/div>\n

Equipamiento<\/h1>\n
\n
    \n
  • Laboratorio equipado para cultivo celular (estufas, campanas y microscopio) y expresi\u00f3n de prote\u00ednas (WB), PCR, electroforesis y centr\u00edfugas.<\/li>\n
  • Histolog\u00eda e Inmunohistoqu\u00edmica: micr\u00f3tomo, equipamiento para inclusi\u00f3n de tejidos.\u00a0 Equipamiento para estudios de animales in vivo, tensi\u00f3metro para roedores.<\/li>\n
  • Disponibilidad y acceso a animalario experimental (en la misma planta).<\/li>\n<\/ul>\n<\/div>\n

    Colaboradores<\/h1>\n
    \n
      \n
    • Mar\u00eda Isabel Arenas Jim\u00e9nez<\/em><\/strong>,\u00a0 Profesora Titular de Universidad.<\/li>\n
    • Mar\u00eda Jos\u00e9 Carmena Sierra, Catedr\u00e1tica de Universidad<\/em><\/strong>.<\/li>\n
    • Mar\u00eda del Carmen Mu\u00f1oz Moreno<\/em><\/strong>, Profesora Titular de Universidad.<\/li>\n
    • Eduardo Arilla Ferrero, Catedr\u00e1tica de Universidad<\/em><\/strong>.<\/li>\n
    • Rafael Moreno G\u00f3mez-Toledano<\/em><\/strong>, Contratado predoctoral.<\/li>\n
    • Coral Garc\u00eda Pastor, Contratada predoctoral<\/strong><\/em>.<\/li>\n<\/ul>\n<\/div>\n

      Publicaciones<\/h1>\n
      \n
        \n
      • Paula Reventun; Matilde Alique; Irene Cuadrado; Susana Marquez; Rocio Toro; Carlos Zaragoza; Marta Saura. 2017. iNOS derived Nitric Oxide induces integrin-linked kinase (ILK) endocytic lysosome-mediated degradation in the vascular endothelium Arteriosclerosis, Thrombosis, and Vascular Biology. LIPPINCOTT WILLIAMS & WILKINS. 37-7, pp.1272-1281. ISSN 1079-5642. WOS (19), SCOPUS (19) https:\/\/doi.org\/10.1161\/ATVBAHA.117.309560<\/li>\n
      • Ceprian, N.; Valera, G.; Caro, J.; et al; Carracedo, J.2021. Effect of Kidney Transplantation on Accelerated Immunosenescence and Vascular Changes Induced by Chronic Kidney Disease.Frontiers in medicine. 8, pp.705159. ISSN 2296-858X. https:\/\/doi.org\/10.3389\/fmed.2021.705159<\/li>\n
      • Carmen Vida; Julia Carracedo; Patricia de Sequera; Guillermo Bodega; Rafael Perez; Matilde Alique; Rafael Ramirez. 2020. A high magnesium concentration in citrate dialysate prevents oxidative stress and damage in human monocytes in vitro Clinical Kidney Journal. Oxford Academy. ISSN 2048-8505.<\/li>\n
      • Carmen Vida; Julia Carracedo; Patricia de Sequera; Guillermo Bodega; Rafael Perez; Matilde Alique; Rafael Ram\u00edrez. 2020. Increasing the Magnesium Concentration in Various Dialysate Solutions Differentially Modulates Oxidative Stress in a Human Monocyte Cell Line Antioxidants. MDPI. 9-319.<\/li>\n
      • Matilde Alique; Guillermo Bodega; Elena Corchete; et al;. 2020. Microvesicles from indoxyl sulfate-treated endothelial cells induce vascular calcification in vitro Computational and Structural Biotechnology Journal. Elsevier. 18, pp.953-966. ISSN 2001-0370. WOS (15), SCOPUS (17)<\/li>\n
      • Matilde Alique; Guillermo Bodega; Chiara Giannarelli; Julia Carracedo; Rafael Ramirez. 2019. Hypoxia-Inducible Factor-1a regulates migration, proliferation and angiogenesis in replicative endothelial senescence independently of microRNA-126 expression Scientific Reports. Nature. ISSN 2045-2322. WOS (23), SCOPUS (26) https:\/\/doi.org\/10.1038\/s41598-019-43689-3<\/li>\n
      • Estefanya Garcia Menendez; Mar\u00eda Marques; Matilde Alique; et al;. 2019. Statins and antiplatelet agents are associated with changes in the circulatory markers of endothelial dysfunction in chronic kidney disease Nefrologia. ISSN 1989-2284. WOS (2), SCOPUS (2) https:\/\/doi.org\/10.1016\/j.nefro.2018.11.001<\/li>\n
      • Julia Carracedo; Rafael Ram\u00edrez-Carracedo; Irene Mart\u00ednez de Toda; Carmen Vida; Matilde Alique; F\u00e1tima de la Fuente; Rafael Ram\u00edrez. 2018. Protein Carbamylation: A Marker Reflecting Increased Age-Related Cell Oxidation International Journal of Molecular Sciences. MDPI. 19-5. ISSN 1422-0067. WOS (20), SCOPUS (22) https:\/\/doi.org\/10.3390\/ijms19051495<\/li>\n
      • Guillermo Bodega; Matilde Alique; Lourdes Bohorquez; et al;. 2018. Young and Especially Senescent Endothelial Microvesicles Produce NADPH: The Fuel for Their Antioxidant Machinery Oxidative medicine and cellular longevity. Hindawi. 2018-12, pp.1-12. ISSN 1942-0994. WOS (21), SCOPUS (22) https:\/\/doi.org\/10.1155\/2018\/3183794<\/li>\n
      • Patricia Sequera Ortiz; Elena Corchete; Lourdes Bohorquez; et al;. 2017. Residual Renal Function in Hemodialysis and Inflammation Therapeutic Apheresis and Dialysis. WILEY. 21-6, pp.592-598. ISSN 1744-9987. WOS (14), SCOPUS (12) https:\/\/doi.org\/10.1111\/1744-9987.12576<\/li>\n
      • Guillermo Bodega; Matilde Alique; Lourdes Bohorquez; Sergio Ciordia; Maria Mena; Rafael Ramirez. 2017. The antioxidant machinery of young and senescent human umbilical vein endothelial cells and their microvesicles Oxidative Medicine and Cellular Longevity. Hindawi. 7094781. ISSN 1942-0994. WOS (21), SCOPUS (19) https:\/\/doi.org\/10.1155\/2017\/7094781<\/li>\n
      • David Rodriguez; Urooj Zafar; Daniel Christoffel; et al;. 2017. Susceptibility to Chronic Social Stress Increases Plaque Progression, Vulnerability and Platelet Activation Thrombosis and Haemostasis. GEORG THIEME VERLAG KG. 117-4, pp.816-818. ISSN 0340-6245. WOS (12), SCOPUS (12) https:\/\/doi.org\/10.1160\/TH16-10-0817<\/li>\n
      • Alique, M.; Ru\u00edz Torres, MP.; Bodega, G.; et al; Ram\u00edrez, R.2017. Microvesicles from the plasma of elderly subjects and from senescent endothelial cells promote vascular calcification. Aging. IMPACT JOURNALS LLC. 9-3, pp.778-789. ISSN 1945-4589. WOS (58), SCOPUS (61) https:\/\/doi.org\/10.18632\/aging.101191<\/li>\n
      • Julia Carracedo; Rafael Ram\u00edrez Carracedo; Matilde Alique; Rafael Ram\u00edrez Chamond. 2017. Endothelial Cell senescence in the pathogenesis of endothelial dysfunction Endothelial Dysfunction (Edited by Helena Lenasi). InTech \u2013 open science. ISBN 978-953-51-5698-7. https:\/\/doi.org\/10.5772\/intechopen.73024<\/li>\n
      • Figuer, A.; Bodega, G.; Tato, P.; et al; Alique, M.2021. Premature Aging in Chronic Kidney Disease: The Outcome of Persistent Inflammation beyond the Bounds.International journal of environmental research and public health. 18-15. ISSN 1660-4601. https:\/\/doi.org\/10.3390\/ijerph18158044<\/li>\n
      • Julia Carracedo; Matilde Alique; Carmen Vida; et al;. 2020. Mechanisms of Cardiovascular Disorders in Patients With Chronic Kidney Disease: A Process Related to Accelerated Senescence Frontiers in Cell and Developmental Biology. Frontiers. 8-185. ISSN 2296-634X. WOS (34), SCOPUS (35)<\/li>\n
      • Matilde Alique; Elsa Sanchez-Lopez; Guillermo Bodega; Chiara Giannarelli; Julia Carracedo; Rafael Ramirez. 2020. Hypoxia-Inducible Factor-1\u03b1: The Master Regulator of Endothelial Cell Senescence in Vascular Aging Cells. MDPI. 9-1. ISSN 2073-4409. WOS (25), SCOPUS (27) https:\/\/doi.org\/10.3390\/cells9010195<\/li>\n
      • Matilde Alique; Julia Carracedo; Rafael Ram\u00edrez-Carracedo; Guillermo Bodega; Rafael Ram\u00edrez. 2019. Endothelial Extracellular Vesicles Produced by Senescent Cells: Pathophysiological Role in the Cardiovascular Disease Associated with all Types of Diabetes Mellitus Current Vascular Pharmacology. 16. ISSN 1570-1611. WOS (18), SCOPUS (18) https:\/\/doi.org\/10.2174\/1570161116666180820115726<\/li>\n
      • Guillermo Bodega; Matilde Alique; Lilian Puebla; Julia Carracedo; Rafael Ram\u00edrez. 2019. Microvesicles: ROS scavengers and ROS producers Journal of Extracellular Vesicles. 2019 Jun 17;8(1):162. ISSN 2001-3078. WOS (106), SCOPUS (107) https:\/\/doi.org\/10.1080\/20013078.2019.1626654<\/li>\n
      • Matilde Alique; Rafael Ram\u00edrez-Carracedo; Guillermo Bodega; Julia Carracedo; Rafael Ram\u00edrez. 2018. Senescent Microvesicles: A Novel Advance in Molecular Mechanisms of Atherosclerotic Calcification International Journal of Molecular Sciences. MDPI. 19-7, pp.2003. ISSN 1661-6596. WOS (28), SCOPUS (27) https:\/\/doi.org\/10.3390\/ijms19072003<\/li>\n
      • Julia Carracedo; Isabel Corpas; Matilde Alique; Rafael Ram\u00edrez-Carracedo; Rafael Ram\u00edrez. 2018. Role of microvesicles as biomarkers and future pharmacology targets of cardiovascular diseases (Papel de las microves\u00edculas como biomarcadores y futuras dianas farmacol\u00f3gicas de enfermedades cardiovasculares) Anales de la Real Academia Nacional de Farmacia. RANF. 84, pp.4-15. ISSN 1697-4271.<\/li>\n
      • Ramirez, Rafael; Ceprian, Noemi; Figuer, Andrea; Valera, Gemma; Bodega, Guillermo; Alique, Matilde; Carracedo, Julia. 2022. Endothelial Senescence and the Chronic Vascular Diseases: Challenges and Therapeutic Opportunities in Atherosclerosis JOURNAL OF PERSONALIZED MEDICINE. 12. ISSN 2075-4426. WOS (1) https:\/\/doi.org\/10.3390\/jpm12020215<\/li>\n
      • New environmental factors related to diabetes risk in humans: Emerging bisphenols used in synthesis of plastics. Moreno-G\u00f3mez-Toledano R, Delgado-Mar\u00edn M, Cook-Calvete A, Gonz\u00e1lez-Cucharero C, Alcharani N, Jim\u00e9nez-Guirado B, Hernandez I, Ramirez-Carracedo R, Tesoro L, Botana L, S\u00e1nchez-Esteban S, Diez-Mata J, Zamorano JL, Bosch RJ, Zaragoza C, Saura M.World J Diabetes. 2023 Aug 15;14(8):1301-1313. doi: 10.4239\/wjd.v14.i8.1301.<\/li>\n
      • Combination of Bisphenol A and Its Emergent Substitute Molecules Is Related to Heart Disease and Exerts a Differential Effect on Vascular Endothelium. Moreno-G\u00f3mez-Toledano R, Delgado-Mar\u00edn M, S\u00e1nchez-Esteban S, Cook-Calvete A, Ortiz S, Bosch RJ, Saura M.Int J Mol Sci. 2023 Jul 29;24(15):12188. doi: 10.3390\/ijms241512188.<\/li>\n
      • Endothelial ILK induces cardioprotection by preventing coronary microvascular dysfunction and endothelial-to-mesenchymal transition. Reventun P, S\u00e1nchez-Esteban S, Cook-Calvete A, Delgado-Mar\u00edn M, Roza C, Jorquera-Ortega S, Hernandez I, Tesoro L, Botana L, Zamorano JL, Zaragoza C, Saura M.Basic Res Cardiol. 2023 Jul 14;118(1):28. doi: 10.1007\/s00395-023-00997-0.<\/li>\n
      • NIL10: A New IL10-Receptor Binding Nanoparticle That Induces Cardiac Protection in Mice and Pigs Subjected to Acute Myocardial Infarction through STAT3\/NF-\u03baB Activation. Tesoro L, Hern\u00e1ndez I, Ram\u00edrez-Carracedo R, D\u00edez-Mata J, Alcharani N, Jim\u00e9nez-Guirado B, Ovejero-Paredes K, Filice M, Zamorano JL, Saura M, Zaragoza C, Botana L.Pharmaceutics. 2022 Sep 26;14(10):2044. doi: 10.3390\/pharmaceutics14102044.<\/li>\n
      • Integrin-Linked Kinase Expression in Human Valve Endothelial Cells Plays a Protective Role in Calcific Aortic Valve Disease. S\u00e1nchez-Esteban S, Castro-Pinto M, Cook-Calvete A, Revent\u00fan P, Delgado-Mar\u00edn M, Benito-Manzanaro L, Hernandez I, L\u00f3pez-Menendez J, Zamorano JL, Zaragoza C, Saura M.Antioxidants (Basel). 2022 Aug 31;11(9):1736. doi: 10.3390\/antiox11091736.<\/li>\n
      • Theranostic Contribution of Extracellular Matrix Metalloprotease Inducer-Paramagnetic Nanoparticles Against Acute Myocardial Infarction in a Pig Model of Coronary Ischemia-Reperfusion. Ramirez-Carracedo R, Sanmartin M, Ten A, Hernandez I, Tesoro L, Diez-Mata J, Botana L, Ovejero-Paredes K, Filice M, Alberich-Bayarri A, Mart\u00ed-Bonmat\u00ed L, Largo-Aramburu C, Saura M, Zamorano JL, Zaragoza C.Circ Cardiovasc Imaging. 2022 Jun;15(6):e013379. Doi: 10.1161\/CIRCIMAGING.121.013379.<\/li>\n
      • New Evidence of Renal and Cardiovascular Alterations Promoted by Bisphenol A. Moreno-G\u00f3mez-Toledano R, Arenas MI, V\u00e9lez-V\u00e9lez E, Saura M, Bosch RJ.Biomolecules. 2021 Nov 8;11(11):1649. doi: 10.3390\/biom11111649.<\/li>\n
      • Bisphenol A Induces Accelerated Cell Aging in Murine Endothelium. Moreno-G\u00f3mez-Toledano R, S\u00e1nchez-Esteban S, Cook A, M\u00ednguez-Moratinos M, Ram\u00edrez-Carracedo R, Revent\u00fan P, Delgado-Mar\u00edn M, Bosch RJ, Saura M.Biomolecules. 2021 Sep 29;11(10):1429. doi: 10.3390\/biom11101429.<\/li>\n
      • Aging-related ILK levels are associated with calcified aortic valve and circulating miR 199-3p levels. S\u00e1nchez-Esteban S, Cook A, Revent\u00fan P, Zaragoza C, Zamorano JL, Saura M.Rev Esp Cardiol (Engl Ed). 2022 Jan;75(1):88-91. doi: 10.1016\/j.rec.2021.06.007.<\/li>\n
      • miR-16 induces endoplasmic reticulum stress in ischemic dilated cardiomyopathy. S\u00e1nchez-Esteban S, Zaragoza C, Saura M.Rev Esp Cardiol (Engl Ed). 2021 Sep;74(9):732-733. doi: 10.1016\/j.rec.2021.03.003.<\/li>\n
      • Bisphenol A impaired cell adhesion by altering the expression of adhesion and cytoskeleton proteins on human podocytes. Moreno-G\u00f3mez-Toledano R, Arenas MI, Gonz\u00e1lez-Mart\u00ednez C, Olea-Herrero N, Revent\u00fan P, Di Nunzio M, S\u00e1nchez-Esteban S, Arilla-Ferreiro E, Saura M, Bosch RJ.<\/li>\n
      • Sci Rep. 2020 Oct 6;10(1):16638. doi: 10.1038\/s41598-020-73636-6.<\/li>\n
      • Bisphenol A induces coronary endothelial cell necroptosis by activating RIP3\/CamKII dependent pathway. Reventun P, Sanchez-Esteban S, Cook A, Cuadrado I, Roza C, Moreno-Gomez-Toledano R, Mu\u00f1oz C, Zaragoza C, Bosch RJ, Saura M. Sci Rep. 2020 Mar 6;10(1):4190. doi: 10.1038\/s41598-020-61014-1.<\/li>\n
      • iNOS-Derived Nitric Oxide Induces Integrin-Linked Kinase Endocytic Lysosome-Mediated Degradation in the Vascular Endothelium.Reventun P, Alique M, Cuadrado I, M\u00e1rquez S, Toro R, Zaragoza C, Saura M. Arterioscler Thromb Vasc Biol. 2017 Jul;37(7):1272-1281. doi: 10.1161\/ATVBAHA.117.309560<\/li>\n
      • Bisphenol a Exposure and Kidney Diseases: Systematic Review, Meta-Analysis, and NHANES 03-16 Study. Moreno-G\u00f3mez-Toledano R, Arenas MI, V\u00e9lez-V\u00e9lez E, Coll E, Quiroga B, Bover J, Bosch RJ.Biomolecules. 2021 Jul 16;11(7):1046. doi: 10.3390\/biom11071046.<\/li>\n
      • Yago-Ib\u00e1\u00f1ez J, Mu\u00f1oz-Moreno L, Gallego-Tamayo B, Lucio-Caza\u00f1a FJ, Fern\u00e1ndez-Mart\u00ednez AB. Prostaglandin transporter PGT as a new pharmacological target in the prevention of inflammatory cytokine-induced injury in renal proximal tubular HK-2 cells. Life Sci. 2023 Jan 15;313:121260. doi: 10.1016\/j.lfs.2022.121260. Epub 2022 Dec 5. PMID: 36473541.<\/li>\n
      • Garc\u00eda-Pastor C, Benito-Mart\u00ednez S, Bosch RJ, Fern\u00e1ndez-Mart\u00ednez AB, Lucio-Caza\u00f1a FJ. Intracellular prostaglandin E2 contributes to hypoxia-induced proximal tubular cell death. Sci Rep. 2021 Mar 29;11(1):7047. doi: 10.1038\/s41598-021-86219-w. PMID: 33782420; PMCID: PMC8007803.<\/li>\n
      • Yago-Ib\u00e1\u00f1ez J, Garc\u00eda-Pastor C, Lucio-Caza\u00f1a FJ, Fern\u00e1ndez-Mart\u00ednez AB.Retinoic acid receptor-beta prevents cisplatin-induced proximal tubular cell death. Biochim Biophys Acta Mol Basis Dis. 2020 Apr 8:165795. doi: 10.1016\/j.bbadis.2020.165795. Garcia-Pastor, C., Blazquez-Serra, R., Bosch, R. J., Lucio Caza\u00f1a, F. J., & Fernandez-Martinez, A. B. Apoptosis and cell proliferation in proximal tubular cells exposed to apoptotic bodies. Novel pathophysiological implications in cisplatin-induced renal injury. Biochimica et Biophysica Acta. Molecular Basis of Disease.2019 Jun 8.<\/li>\n<\/ul>\n<\/div>\n


        \n<\/p>\n","protected":false},"excerpt":{"rendered":"

        Grupo Cifra 2 – UAH Ricardo Jos\u00e9 Bosch Mart\u00ednez Francisco J. de Lucio Caza\u00f1a Ricardo J Bosch. Catedr\u00e1tico em\u00e9rito del Dpto Biol Sistemas, UAH . Investiga en el \u00e1rea de la nefropat\u00eda inducida por el factor ambiental bisfenol A (BFA) y la nefropat\u00eda diab\u00e9tica (ND). Actualmente se est\u00e1n realizando estudios traslacionales en poblaciones de alto […]<\/p>\n","protected":false},"author":2,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-277","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/cifra2-cm.com\/index.php\/wp-json\/wp\/v2\/pages\/277","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/cifra2-cm.com\/index.php\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/cifra2-cm.com\/index.php\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/cifra2-cm.com\/index.php\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/cifra2-cm.com\/index.php\/wp-json\/wp\/v2\/comments?post=277"}],"version-history":[{"count":45,"href":"https:\/\/cifra2-cm.com\/index.php\/wp-json\/wp\/v2\/pages\/277\/revisions"}],"predecessor-version":[{"id":821,"href":"https:\/\/cifra2-cm.com\/index.php\/wp-json\/wp\/v2\/pages\/277\/revisions\/821"}],"wp:attachment":[{"href":"https:\/\/cifra2-cm.com\/index.php\/wp-json\/wp\/v2\/media?parent=277"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}